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Grant: The role of chronic immune stimulation by active HHV-6 infection/coinfections in immune dysfunction and development of lymphoma PI: Daniel L. Peterson, MD, Sierra Internal Medicine, Nevada, USA Dr. Dan Peterson of Sierra Internal Medicine plans to study the possible correlation between chronic inflammatory stimulation from active and chronic HHV-6 infections, Chronic Fatigue Syndrome, autoimmune disease, and rare form of lymphoma. Previous studies have shown that CFS patients have an increased incidence of lymphoproliferative malignancy compared to the normal population. While the incidence of non-Hodgkin’s lymphoma is 0.02% in the United States, approximately 5% of the CFS patients positive for HHV-6A have developed the malignacy. Additionally, 12% of those patients examined demonstrated T cell beta chain rearrangement. Dr. Peterson will utilize a viral gene micorarray containing sequences of every known mammalian virus to determine the specific viruses expressed in CFS patients with TCR-y gene rearrangements, chromosomal integration of HHV-6 and a rare mantle cell lymphoma. Peterson will also perform analysis to determine if oligoclonal or monoclonal rearrangement of TCR-y genes occurs with increased frequency in people with chromosomal integration of HHV-6. Finally, chromosomal integration data will be correlated with other parameters such as the development of lymphoma using Dr. Peterson’s extensive database of thousands of patients.
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