Associated Conditions HHV-6 & Lung Disease

HHV-6 & Lung Disease

The development of interstitial pneumonia and pneumonitis is often associated with HHV-6 infection/reactivation in patients who have undergone transplantation (Yamamoto 2005, Bommer 2009, Costa 2010, Mariotte 2011). Furthermore, the detection of HHV-6 DNA in the bronchalveolar lavage fluid has been identified as a risk factor for the development of bronchiolitis obliterans syndrome (Neurohr 2005) and organizing pneumonia (Costa 2010) in lung transplant patients. Acute respiratory failure due to HHV-6 has been successfully treated with foscarnet antiviral therapy (Mariotte 2011).

Key Papers: HHV-6 & Lung Disease

Costa

2011

Quantitative detection of HHV-6 and HHV-7 in transbronchial biopsies from lung transplant recipients.
Mariotte

2011

Significance of herpesvirus 6 in BAL fluid of hematology patients with acute respiratory failure.
Costa

2010

Herpesviruses detection by quantitative real-time polymerase chain reaction in bronchoalveolar lavage and transbronchial biopsy in lung transplant: viral infections and histopathological correlation
Bommer

2009

Challenging complications of treatment – human herpes virus 6 encephalitis and pneumonitis in a patient undergoing autologous stem cell transplantation for relapsed Hodgkin’s disease: a case report
Hennus

2009

Life-threatening human herpes virus-6 infection in early childhood: presenting symptom of a primary immunodeficiency?
Neurohr

2005

Human herpesvirus 6 in bronchalveolar lavage fluid after lung transplantation: a risk factor for bronchiolitis obliterans syndrome?
Yamamoto

2005

HHV-6 and 7 DNA loads in lung tissues collected from patients with interstitial pneumonia.
Nagate

2001

Detection and quantification of human herpesvirus 6 genomes using bronchoalveolar lavage fluid in immunocompromised patients with interstitial pneumonia.
Buchbinder

2000

Human herpesvirus 6 is an important pathogen in infectious lung disease after allogeneic bone marrow transplantation
Cone

1996

Coinfection with human herpesvirus 6 variants A and B in lung tissue
Hammerling

1996

Prevalence of human herpesvirus 6 in lung tissue from children with pneumonitis
Cone

1994

Human herpesvirus 6 and pneumonia.
Carrigan

1991

Interstitial pneumonitis associated with human herpesvirus-6 infection after marrow transplantation.


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